She was born 5 February 1838, in Bothwell. She was married to Theophilus MacDonald and lived in Kingsboro. She died 8 December 1874 during childbirth, and was buried in Kingsboro in the Baptist Cemetery. Lydia and Theophilus were first cousins. It is unclear at this time whether she is the mother of Joshua F. MacDonald, or whether Theophilus' second wife, Ann Leet, is. Lydia may likely have been his mother, as the name "Lydia" continues on in the family lineage to this day.